PREPARATION OF 70% ETHANOL EXTRACT OF PUMPKIN NANOPARTICLES (SECHIA EDULLE) USING THE INONIC GELATION METHOD IN LOZENGES TABLET FORMULATION
Abstract
Introduction:Chayote is a plant that is efficacious in lowering blood pressure. High blood pressure in hypertension can cause increased morbidity and mortality. These bad effects can be avoided by taking medication regularly. The aim of taking medication regularly is to ensure that drug levels in the blood remain within the therapeutic range. Apart from that, to achieve maximum drug levels in the blood is to make the drug into nanoparticles. Objectives: The aim of this research is to prepare nanoparticles of 70% ethanol extract of Chayote using the ionic gelation method. Methods:The research method is laboratory experimental. The research data is in the form of quantitative data, namely the size of the nanoparticles. Results: Nanoparticle preparation was carried out using a solution of 1% Chitosan and 0.5% Na TPP with a ratio of 2:1. The results of nanoparticle preparation were tested using Particle Size Analysis. The yield weight of the extract was also calculated at 27.73%. The measurement results of 70% Chayote ethanol extract nanoparticles were 556,5 nm. Conclusions: the particle size meets the criteria for nanoparticles of 10-1000 nm (556,5 nm).
Downloads
References
Anas, Y., Cahyani, I.K. dan Sukma, U.F. 2021. Efektivitas Fraksi Aktif Ekstrak Etanol Labu Siam (Sechium edule (Jack) Sw) Sebagai Antihipertensi Pada Tikus Hipertensi Yang Diinduksi Monosodium Glutamat. Jurnal llmu Farmasi dan Farmasi Klinik. 18(1): 1-7.
Choiri, Z., Ronny, M., dan Nanung, D. 2016. Biosintesis dan Karakterisasi Nano-Enkapsulasi Ekstrak Buah Mengkudu (Morinda citrifolia) Dengan Kitosan-Sodium Tripolifosfat Sebagai KandidatAntioksidan Alami. Prosiding Simposium Nasional Penelitian dan Pengembangan Peternakan Tropik. 2016, Yogyakarta, Jawa Tengah. pp. 22-28.
Dipiro, J.T., Yee, G.C., Haines, S.T., Nolin, T.D., Ellingrod, V.L., dan Posey, L.M. 2023. Dipiro's Pharmacotherapy A Pathophysiologic Approach 12th ed. Mc Graw-Hill: Chicago.
Fitri, D.R., Syafei, D. dan Sari, C.P. 2021. Karakteristik Nanopartikel Ekstrak Etanol 70% Daun Jarak Pagar (Jatropha Curcas L.) dengan Metode Gelasi Ionik. Jurnal Farmasi Higea. 13(1): 1-7.
Handani, W.R., Sediawan, W.B., Tawfiequrrahman, A., Wiratni., and Kusumastuti, Y. 2016. The Effect Of Temperature and Chitosan Concentration During Storage On The Growth Of Chitosan Nanoparticle Produced By Ionic Gelation Method. AIP Conference Proceedings. Mei 2017. pp. 1-8.
Hanutami, B. dan Budiman, A. 2014. Review Artikel : Penggunaan Teknologi Nano Pada Formulasi Obat Herbal. Farmaka. 15(2): 29-41.
Kementerian Kesehatan RI. 2017. Farmakope Herbal Edisi II. Jakarta: Kementerian Kesehatan RI.
Kementerian Kesehatan RI. 2018. Hasil Utama Riskesdas 2018. Badan Kementerian dan Pengembangan Kesehatan. Jakarta.
Liu, H., dan Changyou, G. 2009. Preparation And Properties Of Ionically Cross-Linked Chitosan Nanoparticle. Polymers for Advance Technologies. 20(7) : 613-619.
Munawassalmiah, R., Hajrah, dan Rijai, L. 2018. Observasi Klinik Ekstrak Labu Siam (Sechium edule) Sebagai Antihipertensi. Proceeding of Mulawarman Pharmaceuticals Conferences. 20-21 November 2018, Samarinda, Kalimantan Timur. pp. 128–135.
Pakki, E., Sumarheni., Aisyah, F., Ismail., dan Safirahidzni, S. 2016. Formulasi Nanopartikel Ekstrak Bawang Dayak (Eleutherine americana (Aubl) Merr) Dengan Variasi Konsentrasi Kitosan-Tripolifosfat (TPP). J. Trop. Pharm. Chem. 3(4) ; 251-263.
Pratiwi, B.A.M. 2018. Efek Antihipertensi Ekstrak Etanol Labu Siam (Sechium edule) Swartz. Pada Tikus Hipertensi Yang Diinduksi Monosodium Glumat (MSG). Skripsi. Semarang.
Prihantini, M., Wibowo, D.N., Azizah, N., dan Setya, N.F. 2021. Formulasi Dan Uji Stabilitas Antioksidan Krim Nanopartikel Kitosan-Ekstrak Etanol Daun Sirsak (Annona muricata L.) Menggunakan Metode Cycling Test. Jurnal Ilmiah Cendekia Eksakta. 88-93.
Rosado-Perez, J., Aguiniga-Sanchez, I., Santiago-Osorio, E., and Mendoza-Nunez, V.M. 2019. Effect of Sechium edule var.nigrum spinosum (Chayote) on Oxidative Stress and Pro-Inflammatory Markers in Older Adults with Metabolic Syndrome: An Exploratory Study. Antioxidants. 8(5) : 146.
Taurina, W., Martien, R., dan Ismail, H. 2013. Preparasi Nanopartikel Gamavuton-O Menggunakan Kitosan Rantai Pendek dan Tripolifosfat Sebagai Cross Linker. Jurnal Ilmiah Farmasi. 10(2) : 60-68.
Tiyaboonchai, W. 2003. Chitosan Nanoparticles: A Promising System for Drug Delivery. Naresuan University Journal. 11(3) : 51-66.
Wen, T., Brush, L.N., Krishnan, K.M. 2014. A Generalized Diffusion Model For Growth of Nanoparticles Synthesized by Colloidal Methods. Journal Of Colloidal and Interface Science. 419 : 79-85.
Widiyastuti, Y. 2020. Pengembangan Parameter Standar Simplisia Untuk Menjamin Mutu dan Keamanan Obat Tradisional. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI.
Wijaya, D.P. 2013. Preparasi Nanopartikel Sambung Silang Kitosan-Tripolifosfat Yang Mengandung Ginsenosida. Skripsi. Jakarta.
WHO. 2023. Hypertention. URL: https://www.who.int/news-room/fact-sheets/detail/hypertension. Diakses tanggal 5 Februari 2024.
Copyright (c) 2024 Anung Kustriyani, Rindu Ananda Aprilia, Ni Putu Happy Ana Kristina, Alila Fingkita Sari, Rita Gustina
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
