Kajian Kajian In Silico Aktivitas Ekstrak Daun Mangga (Mangifera indica L.) Sebagai Antidiabetes Tipe 2
Type 2 diabetes mellitus is the most common type of diabetes in the world. Type 2 diabetes mellitus is caused by an increase in blood sugar due to a decrease in low insulin secretion by the pancreas gland. Pharmacological therapy for type 2 diabetes, namely oral antidiabetic drugs (OAD) or insulin such as acarbose, metformin, or voglibose has been reported to have side effects. Side effects that occur, such as gastrointestinal disturbances (diarrhea and flatulence), liver disorders, dizziness, nausea and vomiting. Thus, herbal ingredients are an alternative in the treatment of diabetes mellitus. In this study, mango leaf extract, namely mangiferin, was suspected as an antidiabetic compound. The purpose of this study was to determine the interaction of mangiferin which is an extract of mango leaves (Mangifera Indica L.) with -glucosidase in silico. The results showed that mangiferin as a type 2 antidiabetic compound by producing an G value between -glucosidase and mangiferin of -38.89 kcal/mol. The interaction that occurs is hydrogen bonding between mangiferin and amino acid residues Glu553, Asn551, Arg500 and Tyr460, Phe461.
Keywords: α-glucosidase, in silico, mangiferin, mango leaf,
Dabhi, A.S., Bhatt, N.R., Shah, M.J. (2013). Voglibose: an Alpha Glucosidase Inhibitor. J Clin Diagn. 7, 3023–3027.
De Baishakhi, et al. (2015). Computational pharmacokinetics and in vitro-in vivo correlation of antidiabetic synergistic phytocomposite blend. World Journal Of Diabetes. 6 (11), 1179 – 1185.
Devi et. al., 2006. Isolation and Identification of Marine Actinomycetes and their Potential Antimicrobial Activity. http://link.jstor.org. Diakses tanggal 17 Maret 2021
El-sheikh, Nora M (2012). Mangifera indica leaves extract modulates serum leptin, asymmetric dimethylarginine and endothelin-1 levels in experimental diabetes mellitus. The Egyptian Journal of Biochemistry and Molecular Biology. 30(N.2), 229-244.
Ganogpichayagrai, A, C Palanuvej and N Ruangrungsi. (2017). Antidiabetic and anticancer activities of Mangifera indica cv. okrong leaves. Journal of Advanced Pharmaceutical Technology and Research. 8(1), 19-24
Gururaja, GM, D Mundkinajeddu, AS Kumar, SM. Dethe, JJ Allan and A Agarwal. (2017). Evaluation of cholesterollowering activity of standardized extract of Mangifera indica in albino Wistar rats. Pharmacognosy Research. 9(1), 21-26
Mathalaimutoo A, Wilar G dan Wardoyo MM. 2012. Aktivitas antidiabetes ekstrak etanol daun mangga bapang (Mangifera indica L. Var. Bapang) pada tikus galur wistar yang diinduksi aloksan. Jurnal unpad. 1(1)
Mohanvelu, Rajalakshmi, A Sudha Madhuri, S Ramabhimaiah. (2015). Evaluation of analgesic activity of aqueous extract of Mangifera indica leaves in albino rats. International Journal of Basic and Clinical Pharmacology. 4(1), 107-110.
Mustapha, Alqasim Abdullahi., Enemali, M.O., d Olose, M., Owuna, G., Ogaji, J.O., Idris, M.M., dan Aboh, V.O. (2014). Phytoconstituents and Antibacterial Efficacy of Mango (Mangifera indica) Leave Extracts. Journal of Medicinal Plants Studies. 2 (5), 19-23.
National Center for Biotechnology Information. (2021). PubChem Compound Summary for CID 5281647, Mangiferin. https://pubchem.ncbi.nlm.nih.gov/compound/Mangiferin. 17 Maret 2021.
Rajan, S, H Suganya, T Thirunalasundari and S Jeeva. (2012). Antidiarrhoeal efficacy of Mangifera indica seed kernel on swiss albino mice. Asian Pacific Journal of Tropical Medicine. 5(8), 630 -633.
Sahrawat, A., Pal, S., dan Shahi, S.K.. (2013). Antibacterial Activity of Mangifera indica (mango) Leaves Against Drug Resistant Bacterial Strains. International Journal of Advanced Research. 1 (6), 82-86
Shah, K.A., Patel, M.B., Patel, R.J., and Parmar, P.K. (2010). Mangifera Indica (Mango). Pharmacogn Rev. 4(7), 42–48.
Van de Laar F.A.1. (2008). Alpha-Glucosidase Inhibitors in The Early Treatment of Type 2 Diabetes. Vasc Health Risk Manag. 4, 1189-95
Yakubu, MT and SS Salimon. (2015). Antidiarrhoeal activity of aqueous extract of Mangifera indica L. leaves in female albino rats. Journal of Ethnopharmacology. 163, 135 -141.
Copyright (c) 2023 Janatun naimah
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.